Early post-transplant urinary tract infection epidemiology and risk factor

Muhammed Suhaib  Subhi Fakhri Almufti

doi:10.56056/amj.2022.158

Authors

Muhammed Suhaib Subhi Fakhri Almufti

DOI:

https://doi.org/10.56056/amj.2022.158

Keywords:

Renal Transplant, Risk factors, Urinary tract infection

Abstract

Background and objectives: Renal Transplantation became the most successful management for end stage renal failure; postoperative urinary tract infection is the most common complication. The aim is to evaluate the outcome and risk factors of posttransplant urinary tract infection.

Methods: This is a prospective study for renal transplant patients between 2018-2019 in Hawler/ Rizgary and Paky hospital. Patients, who underwent renal transplant, with 1 year follow up. Variable risk factors assessment done including chronic renal failure etiology, preoperative dialysis duration, operation time, length of drain and Foley’s catheter, type of immune suppressive therapy used, time and numbers of hospitalization associated with posttransplant urinary tract infection were examined, the relation between the risk factors and urinary tract infection was evaluated.

Results: Total of 63 patients was involved, 12 had a total of 24 urinary tract infection attacks; the most common isolated microorganisms were E-coli and Klepsiella. The infection frequently appeared during the first 120 days postoperatively. Among the analyzed variables, there was no significant difference. Assessing all the variables, number of hospitalization after discharge were significantly more frequent in the 12 patients with infection attacks, although 31 patients out of 63 had hospitalized, as compared to patients without infection, but this difference was statistically insignificant.

Conclusions: The most significant period for infection in renal transplanted patients after 1 year follow up is the first 4 months postoperatively. Patients who were admitted to hospital for different reasons and those who had preoperative history of urinary tract infection, have a higher risk.

Downloads

Download data is not yet available.

References

Rubin R. Infections in the organ transplant recipient. In: Rubin RH, Young LS, eds. Clinical

approach to infection in the compromised host, 4th ed. New York: Kluwer Academic/Plenum

Publishers, 2002:573-679

Rubin R, Ikonen T, Gummert J, Morris R. The therapeutic prescription for the organ transplant recipient: linkage of immunosuppression and antimicrobial strategies. Trans Infect Dis1999; 1:29-39

Fishman JA. Infection in Organ Transplantation. Am J Transplant.2017; 17: 856–79

Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med. 2007; 357(25):2601-14.

Tolkoff-Rubin NE, Rubin RH. Urinary tract infection in the renal transplant recipient. In:

Bergan T, ed. Urinary tract infections. Basel: Karger 1997, pp 27-33.

Shamila Karuthu and Emily A. Blumberg, Common Infections in Kidney Transplant Recipients.Clin J Am Soc Nephrol.2012;7: 2058–70.

Budde K, Glander P. Pharmacokinetic principles of immunosuppressive drugs. Ann Transplant 2008;13(3):5-10.

Jevnikar AM, Manon RB. Late kidney allograft loss: what we know about it, and what we can do about it. Clin J Am Soc Nephrol 2008;3(2): S56-S67.

Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med

;351(26):2715-29.

Ranganathan M, Akbar M, Ilham MA, Chavez R, Kumar N, Asderakis A. Infective complications associated with ureteral stents in renal transplant recipients. Transplant Proc.