Effect of Body Mass Index on Gastroesophageal Reflux Disease

Sabah Jalal  Shareef

doi:10.56056/amj.2016.12

Authors

Sabah Jalal Shareef Department Of Surgery, College Of Medicine, Hawler Medical University

DOI:

https://doi.org/10.56056/amj.2016.12

Keywords:

Gastroesophageal reflux disease symptoms, body mass index, endoscopic findings

Abstract

Background and objectives: The gastroesophageal reflux disease is a diagnostic and therapeutic challenge in surgery because of its complicated etiology and pathophysiology. Its incidence is increasing parallel with obesity throughout the world. This study tried to find a relation between body mass index and gastroesophageal reflux disease.

Methods: This study done on one hundred gastroesophageal reflux disease patients in Rizgary teaching hospital, Erbil city Kurdistan region of Iraq from Jan 2014 to June 2014, the study attempted to access the relation between body mass index and symptom severity of gastroesophageal reflux disease through reflux episodes known by number of episodes per week, and also impact of body mass index on endoscopic changes.

Results: This study was carried out on 100 patients (%45 male) and (%55 female), the mean age ± SD of participants was 12.5 ± 37.13 from 75-17 years, the body mass index (BMI) classified to normal <25, overweight between (30-25), obese patients>30.The symptoms severity increased with increase body mass index , but its relation with endoscopic findings were not significant.

Conclusions: The effect of increased body mass index on gastroesophageal reflux disease is an increase in reflux episodes, but its relation to endoscopic finding was not significant.

Downloads

Download data is not yet available.

References

Brunicardi F, Andersen D, Billiar T, Dunn D., Hunter J., Mat- thews J (ed.). An esophagus and diaphragmatic hernia, Schwartz-›s Principles of Surgery, 10th edition. New York: Mc Graw-Hill; 2015. P. 966.

Williams N, Bulstrade C, Connel RP (editors). The Esophagus.Bailey & loves, Short Practice of Surgery. Taylor and Francis group; 2013,. P. 995.

Courtney M. Townsen JR., Beauchamp DR, (editors). Esophagus.Sabiston textbook of surgery. Philadelphia: Elsevier; 2012. P. 1030

Beck IT, Champion MC, Lemire S, Thomson AB, Anvari M, Arm- strong D, Bailey RJ, Barkun AN, Boivin M, Bursey RF, et al. The Second Canadian Consensus Conference on the management of Patients with Gastroesophageal Reflux Disease. Can J Gastroen- terol. 1997 Sep;11 (Suppl B):7B–20B. [PubMed].

Wajed SA, Streets CG, Bremner CG, Elevated body mass disrupts the barrier to gastroesophageal reflux. Arch Surg. 2001; 136:1014- 8.

Corley DA, Kubo A Am J Body mass index, and gastroesophageal reflux disease: a systematic review and meta-analysis. Gastroen- terology. 2006; 101(11):2619-28.

Blondeau K, Boecxstaens V, Van Oudenhove L. increasing body weight enhances prevalence and proximal extent of reflux in GERD patients ‹on› and ‹off› PPI therapy. Neurogastroenterol Motil. 2011; 23: 724–e327.

Fornari F, Callegari-Jacques SM, Dantas RO. Obese patients have stronger peristalsis and increased acid exposure in the esophagus. 2011; 56:1420–6.

de Vries DR, Van Herwaarden MA, Smout AJ. Gastroesophageal pressure gradients in gastroesophageal reflux disease: relations with a hiatal hernia, body mass index, & esophageal acid expo- sure.Am JGastroenterol 2008; 103: 1349–54.

Ayazi S, Hagen JA, Chan LS, , DeMeester SR, Lin MW, Ayazi A,Leers JM, Oezcelik A, Banki F, Lipham JC, DeMeester TR et al. Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms. Journal ofGastrointest Surg 2009; 13: 1440–7.

Kuper MA, Kramer KM, Kirschniak A, Kischniak A, Zdichavsky M, Schneider JH, Stuker D, et al. Dysfunction of the lower esoph- ageal sphincter and dysmotility of the tubular esophagus in mor- bidly obese patients. Obes Surg 2009; 19: 1143–9.

Schneider JH, Kuper M, Konigsrainer A. Transient lower esophageal sphincter relaxation in morbid obesity. Surgery 2009; 19: 595–600.

Anggiansah, Sweis R, Anggiansah A, Wong T, Cooper D, Fox M.etal, the effect of obesity on esophageal function, acid exposure and the symptoms of Gastroesophageal reflux Disease. Aliment Phar- macol Ther. 2013;37(5):555-563.

Hashem El-Serag. The association between obesity and GERD: A Review of the Epidemiological Evidence Published online 2008.

Peura DA, Pilmer B. The Effect increasing body mass index on heartburn severity, frequency and response to treatment with Dex- lansoprazole or lansoprazole. 2013;37 (8)

Douglas A. Corley and Ai Kubo. Body mass index and Gastroesophageal Reflux disease: a systematic review and meta-Anal- ysis. American Journal of Gastroenterology. 2006;101(11):2619- 2628.

Nwokediuko S, Ijoma U, Obienu O, Agunyenwa C. Gastroesophageal Reflux Disease a Clinical and Endoscopic Study of Nigerian Patients. The Internet Journal of Gastroenterology. 2008; 101(8) pp. 1900-43.

Tamas GT, Demeter P. Does Body Mass Index associated with the endoscopic severity of gastroesophageal reflux disease. 2004; 12: 49-52