Assessment of the effects of antihypertensive drugs in patients suffering from hypertension in Kurdistan

Mohammed Hasan Almeshhadani; Khasro Adel  Faeq; Kamal Mohammed  Nidhamy; Abdulsatar Kamil  Faeq

doi:10.56056/amj.2017.27

Authors

Mohammed Hasan Almeshhadani Assistant Prof, Medical College.Hawler Medical University
Khasro Adel Faeq Assistant lecturer, Kurdistan Board of Medical Specialties
Kamal Mohammed Nidhamy Assistant Lecturer, Medical College, Hawler Medical University
Abdulsatar Kamil Faeq Lecturer, Medical College, .Hawler Medical University

DOI:

https://doi.org/10.56056/amj.2017.27

Keywords:

Antihypertensive, Blood pressure management, Hypertension, Kurdistan

Abstract

Background and objectives: Hypertension is an important cardiovascular disease that carries a high rate of mortality and morbidity if not controlled. Significant complications of untreated hypertension include vascular atherosclerosis, chronic kidney diseases, and heart failure. The aim of this retrospective study is to improve practitioners' and specialists’ practices in the management of hypertension in the Kurdistan region. This study assesses the response of our local patient population to different first-line and combination therapies for hypertension to identify the most effective approach.

Methods: This is a retrospective study conducted on 500 patients diagnosed with hypertension consisting of equal numbers of males and females. The sample was randomly chosen using stratified random sampling methods whereby patients were finally divided according to the drugs they were prescribed into 5 groups: renin-angiotensin-aldosterone system inhibitors, calcium channel blockers, Diuretics, renin-angiotensin-aldosterone system inhibitors + calcium channel blockers and renin-angiotensin-aldosterone system inhibitors+diuretics. The goal was to achieve a blood pressure of less than 140 mmHg systolic and less than 90 mmHg diastolic, which was maintained for 6 months. The data was inputted into SPSS as categorical variables and analyzed by Chi-square test.

Results: All the drug groups were significantly effective in bringing the blood pressure to the goal. In relation to mono-therapy calcium channel blockers achieve the goal in (82%) and were the most effective drug group in controlling blood pressure, whilst renin-angiotensin-aldosterone system inhibitors + calcium channel blockers achieve the goal in (85%) was the most powerful combination for controlling moderate to severe hypertension. All age groups were responding to treatment.

Conclusions: All the drug groups tested either singly or in combination calcium channel blockers were best for monotherapy, whereas renin - angiotensin - aldosterone system inhibitors + calcium channel blockers were the best effective combination therapy.

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