Significance of B-catenin Immunohistochemical Expression in Colorectal Carcinoma

Zilan Aziz  Abdulrahman; Ava Tahir  Ismael; Jalal Ali  Jalal; Wahda Muhammed  Taib Alnuaimy

doi:10.56056/amj.2018.42

Authors

Zilan Aziz Abdulrahman Department of Histopathology, Rizgary Teaching Hospital, Erbil.
Ava Tahir Ismael Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil.
Jalal Ali Jalal Department of Pathology, College of Medicine, Hawler Medical University, Erbil
Wahda Muhammed Taib Alnuaimy Department of Pathology, College of Medicine, University of Mosul.

DOI:

https://doi.org/10.56056/amj.2018.42

Keywords:

B-catenin, Colorectal cancer, Immunohistochemistry

Abstract

Background and objectives: Colorectal cancer is the third leading cause of cancer death worldwide and B- catenin has a role in the development of colorectal cancer. The objective of this study was to investigate the B-catenin expression of colorectal carcinoma and assess its correlation with some clinicopathological parameters in Erbil, Kurdistan of Iraq.

Methods: Retrospective study of 100 patients with colorectal cancer collected between January 2015 and January 2017. Clinicopathological parameters were investigated in relation to nuclear and cytoplasmic B-catenin expression.

Results: In 100 specimens of colorectal carcinomas was found to be nuclear (21.6%) and cytoplasm (66.1%). B-catenin was expressed more frequently in patients? 50 years (67.9%), and more commonly in females (60.7%). Left side colon was more frequently affected (85.7%) than the right side (14.3%) with a signifi- cant correlation. Well to moderately differentiated tumors showed higher intensity (89.3%) than poorly differentiated cases (10.7%). Non-mucinous tumors (92.9%) stained more intensely than mucinous tumor (7.1%). 52% of tumor cells were grade I, 37% grade II and 11% grade III. The result of association for B-catenin combined nuclear and cyto- plasmic with intensity of nuclear staining was highly significant. Higher staining intensity is observed in patients with positive nodal status (60.7%) and stage III-IV (60.7%) than those of stage I-II (39.3%).

Conlision: B-catenin was studied in 100 specimens of colorectal cancers, with nuclear staining observed in (21.6%) and cytoplasmic reactivity in (66.1%). Significance was found between intensity of immunoexpression and cellular localization of B-catenin, as well as with clinical parameters of increasing age, female gender, and left sided colonic tumors on another hand

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