The Relation between Serum Magnesium Level and Acute Exacerbation of Asthma in Children Admitted to Rapareen Teaching Hospital in Erbil city
DOI:
https://doi.org/10.56056/amj.2018.60Keywords:
Childhood asthma, Erbil city, Serum magnesiumAbstract
Background and objectives: Asthma is a common disease caused by chronic information and increased responsiveness of pulmonary airways with airflow obstruction. Magnesium in extracellular fluid is crucial for normal neuromuscular activities, and its deficiency is associated with increased contractility of smooth muscle cells including bronchiolar wall leading to bronchospasm. The aim of this study is to detect the prevalence of hypomagnesemia among asthmatic children and to find out any significant correlation of hypomagnesemia with asthma in children.
Methods:A case control study performed in Erbil city, from January 2017 to January 2018. One hundred asthmatic patients aged (3-13) years were examined, all of them had acute asthmatic attacks with respiratory distress for which they were admitted to (Rapareen Pediatric Teaching Hospital). The control group included 100 healthy non asthmatic children who visited the hospital with their parents. Blood samples were taken to measure serum magnesium level. Statistical analysis performed by statistical package for the social sciences (SPSS19).
Results: the mean serum magnesium in patients group was (1.91± 0.33) mg/dl and it was significantly lower than control group it (2.03± 0.33) mg/dl. Serum magnesium level decreased with increasing severity of asthma symptoms.
Conclusions: Serum magnesium level is significantly lower in asthmatic children as compared to the control group, serum magnesium level decreased as the duration of asthma is longer but not significantly, there was an inverse relation between serum magnesium and the severity of asthma, no significant change in its serum level was found when steroids and bronchodilators are used
Downloads
References
Omran M, Russell G, Continuing increase in respiratory symptoms and atopy in Aberdeen schoolchildren. BMJ. 1996; 312: 334-36
Seaton A, Soutar A, Mullins J. The increase in hay fever: pollen, particulate matter and SO2 in ambient air. Q J Med. 1996; 89: 279-84.
Das S, Haldar A, Ghosh I, Saha S, Das A, Biswas S. Serum magnesium and stable asthma: Is there a link?.Lung India. 2010; 27(4): 205–208.
Dominguez L, Barbagallo M, Dilorenzo G et al. Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma. Clinical Science. 1998; 95; 137- 142.
Alamoudi O. Hypomagnesaemia in chronic, stable asthmatics: prevalence, correlation with severity and hospitalization. EurRespir J.2000; 16 (3): 427- 31.
Agin K, Darjani H. Blood serum magnesium values in chronic stable asthmatic patients: a case-control study. Tanaffos. 2005; 4 (13):27–32.
Alamoudi O. Electrolyte disturbances in patients with chronic, stable asthma: effect of therapy. Chest. 2001; 120(2): 431–436.
Noppen M, Vanmaele L, Impens N, Schandevyl W. Bronchodilating effect of intravenous magnesium sulfate in acute severe bronchial asthma. Chest. 1990; 97: 373- 6.
Bateman E, Hurd S, Barnes P et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008; 31:143 78.
Lia L. Macro-and microelements imbalance in etiology and progression of bronchial asthma in children.LikSprava. 2013; 4:33 38.
Picado C, Deulofeu R, Lleonart R et al. Dietary micronutrients/ antioxidants and their relationship with bronchial asthma severity. Allergy. 2001; 56 (1) :4 3 - 9.
Hill J, Micklewright A, Lewis S, Britton J. Investigation of the effect of short-term change in dietary magnesium intake in asthma. EurRespirJ.1997; 10 (10): 2225- 9.
Alamoudi O. Electrolyte disturbances in patients with chronic, stable asthma: effect of therapy. Chest. 2001; 120(2): 431–6.
Zervas E, Papatheodorou G, Psathakis K, Panagou P, Georgatou N, Loukides S. Reduced intracellular Mg concentrations in patients with acute asthma. Chest 2003; 123 (1): 113-8.
Kakish K. Serum Magnesium Levels in Asthmatic Children During and Between Exacerbations .Arch PediatrAdolesc Med. 200
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Dilan Ramzy Pirdawo, Abbas Abdulqadr Alrabbaty
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The copyright on any article published in AMJ (The Scientific Journal of Kurdistan Higher Council of Medical Specialties )is retained by the author(s) in agreement with the Creative Commons Attribution Non-Commercial ShareAlike License (CC BY-NC-SA 4.0)
