Clinical evaluation of motor neuron disease in Erbil Governorate: A cross-sectional study

Mansour Fakher  Hado; Abdulrahman Aziz  Rasoul

doi:10.56056/amj.2023.209

Authors

Mansour Fakher Hado M.B.Ch.B. Khcms trainee. Rizgary Teaching Hospital
Abdulrahman Aziz Rasoul Consultant neurologist F.I.B.M.S. (Neurology), lecturer in Kurdistan Higher Council of Medical Specialties

DOI:

https://doi.org/10.56056/amj.2023.209

Keywords:

Dermal type, Melasma, Thyroid hormones

Abstract

Background & Objectives: Melasma is an acquired hyperpigmented patches dispersed symmetrically on body parts that are exposed to sun, mostly on face of female patients. The precise etiology is obscure, but it has numerous hazards such as; ultra violet exposure, genetic factors, hormonal imbalances like thyroid hormone abnormalities. In this study we aimed to evaluate serum thyroid hormones levels in melasma patients.

Methods: A complete of 51 female patients with melasma were enrolled during this study over a period of six months. The cases were clinically diagnosed and examined by Wood’s light, then sent for thyroid hormone levels assessment and the finding were reported.

Results: In the current study 51 females with melasma. Their ages ranged between (19-46) years, with (59.9%) between (28-38) years. The duration of melasma was from 6 months to 9 years. Thirty-eight of them were married and had pregnancy. Thyroid stimulating hormone levels were high in 22 of them (43.1%), 20 out of 22 cases that was had high levels of thyroid stimulating hormone had dermal type of melasma by Wood’s lamp examination and their p-value was significant (0.001).

Conclusion: We found significantly high levels of thyroid stimulating hormone in cases of melasma mainly among those of dermal type.

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References

Logroscino G, Piccininni M, Marin B, et al. Global, regional, and national burden of motor neu-ron diseases 1990–2016 : a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2018 ;17(12): 1083-97.

Hardiman O, Al-Chalabi A, Chio A, et al. Amyotrophic lateral sclerosis. Nat Rev Dis Prime. 2017 ; 3 : 17071.

Marin B, Logroscino G, Boumédiene F, et al. Clinical and demographic factors and outcome of amyotrophic lateral sclerosis in relation to population ancestral origin. Eur J Epidemiol. 2016 ; 31(3): 229-45.

Kiernan MC, Vucic S, Cheah BC, et al. Amyotrophic lateral sclerosis. Lancet. 2011 ; 377(9769): 942-55.

Shahrizaila N, Sobue G, Kuwabara S, et al. Amyotrophic lateral sclerosis and motor neuron syndromes in Asia. J Neurol Neurosurg Psychiatry. 2016 ; 87(8): 821-30.

De Jongh AD, van Eijk RP, Peters SM, et al. Incidence, prevalence, and geographical clustering of motor neuron disease in the Netherlands. Neurology. 2021 ; 96(8): e1227-36.

Swinnen B, Robberecht W. The phenotypic variability of amyotrophic lateral sclerosis. Nat Rev Neurol. 2014 ; 10(11) :661-70.

Al-Chalabi A, Fang F, Hanby MF, et al. An estimate of amyotrophic lateral sclerosis heritabili-ty using twin data. J Neurol Neurosurg Psychiatry. 2010 ; 81(12): 1324-6.

Al-Chalabi A, Hardiman O. The epidemiology of ALS : a conspiracy of genes, environment and time. Nat Rev Neurol. 2013 ; 9(11) :617-28.

Barohn RJ, Dimachkie MM, Jackson CE. A pattern recognition approach to the patient with a suspected myopathy. Neurol Clin. 2014 ; 32(3):569-93.

Marin B, Boumédiene F, Logroscino G, et al. Variation in worldwide incidence of amyo-trophic lateral sclerosis: a meta-analysis. Int J Epidemiol. 2017 ; 46(1) : 57-74.

Marin B, Fontana A, Arcuti S, et al. Age-specific ALS incidence : a dose-response meta-analysis. Eur J Epidemiol 2018 ; 33(7) : 621-34.

Liewluck T, Saperstein DS. Progressive muscular atrophy. Neurol Clin. 2015; 33(4): 761-73.

Chen L, Zhang B, Chen R, et al. Natural history and clinical features of sporadic amyotro-phic lateral sclerosis in China. J Neurol Neurosurg Psychiatry. 2015 ; 86(10): 1075-81.

Wei Q, Chen X, Zheng Z, et al. Clinical features of amyotrophic lateral sclerosis in south-west China. Amyotroph Lateral Scler Frontotemporal Degener 2015 ; 16(7-8): 512–19.

Liu MS, Cui LY, Fan DS. Age at onset of amyotrophic lateral sclerosis in China. Acta Neurol Scand 2014 ; 129(3) : 163–7.

Nalini A, Thennarasu K, Gourie-Devi M, et al. Clinical characteristics and survival pattern of 1,153 patients with amyotrophic lateral sclerosis: experience over 30 years from India. J Neurol Sci 2008 ; 272(1-2): 60–70.

Quinn C, Elman L. Amyotrophic lateral sclerosis and other motor neuron diseases. CONTINUUM : Lifelong Learning in Neurology. 2020; 26(5): 1323-47.

Brooks BR, Miller RG, Swash M, Munsat TL; World Federation of Neurology Research Group on Motor Neuron Diseases. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000; 1(5): 293–9.

Chiò A, Logroscino G, Traynor BJ, et al. Global epidemiology of amyotrophic lateral scle-rosis: a systematic review of the published literature. Neuroepidemiology. 2013 ; 41(2) :118-30.

Traxinger K, Kelly C, Johnson BA, et al. Prognosis and epidemiology of amyotrophic lateral sclerosis: analysis of a clinic population, 1997–2011. Neurol Clinical Pract 2013 ; 3(4):313-20.

Logroscino G, Traynor BJ, Hardiman O, et al. Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. J Neurol Neurosurg Psychiatry. 2008 ;79(1):6-11.

Alonso A, Logroscino G, Jick SS, Hernán MA. Incidence and lifetime risk of motor neu-ron disease in the United Kingdom: a population based study. Eur J Neurol. 2009 ; 16(6): 745-51.

McCombe PA, Henderson RD. Effects of gender in amyotrophic lateral sclerosis. Gend Med. 2010 ; 7(6):557-70.

Manjaly ZR, Scott KM, Abhinav K, et al. The sex ratio in amyotrophic lateral sclerosis: a population based study. Amyotroph Lateral Scler 2010 ; 11(5):439–42.

Jawdat O, Statland JM, Barohn RJ, Katz J, Dimachkie MM. ALS Regional Variants (Bra-chial Amyotrophic Diplpegia, Leg Amyotrophic Diplegia, and Isolated Bulbar ALS). Neurol Clin. 2015; 33(4): 775-85.

Wijesekera LC, Mathers S, Talman P, et al. Natural history and clinical features of the flail arm and flail leg ALS variants. Neurology. 2009; 72(12): 1087-94.

Katz JS, Wolfe GI, Andersson PB, et al. Brachial amyotrophic diplegia: a slowly progres-sive motor neuron disorder. Neurology. 1999; 53(5): 1071-6.

Kraemer M, Buerger M, Berlit P. Diagnostic problems and delay of diagnosis in amyotro-phic lateral sclerosis. Clin Neurol Neurosurg. 2010; 112(2): 103-5.

Benjaminsen E, Alstadhaug KB, Gulsvik M, Baloch FK, Odeh F. Amyotrophic lateral sclerosis in Nordland County, Norway, 2000–2015: prevalence, incidence, and clinical features. Amyotroph Lateral Scler Frontotemporal Degener. 2018; 19(7-8): 522-7.

Chiò A, Calvo A, Moglia C, Mazzini L, Mora G. Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study. J Neurol Neurosurg Psychiatry. 2011; 82(7): 740-6.

Couratier P, Corcia P, Lautrette G, et al. Epidemiology of amyotrophic lateral sclerosis: a review of literature. Rev Neurol (Paris). 2016; 172(1): 37-45.