Effect of Flurbiprofen spray on postoperative tonsillectomy pain

Authors

  • Abdulkhaliq Kerim Hamad Emin M.B. Ch. B. PhD. Consultant Otolaryngologist

DOI:

https://doi.org/10.56056/amj.2019.92

Keywords:

Flurbiprofen spray, Tonsillectomy pain

Abstract

Background and objectives: Tonsillectomy is one of the most frequently performed surgical procedures. Up to date there are no guidelines for pain control following tonsillectomy. The aim was to determine whether oral spray flurbipro- fen reduces pain and has an influence on wound healing following tonsillectomy.

Methods: A Prospective, randomized study was done in Rizgary Teaching Hospital (Erbil-Iraq). This study was conducted on 60 patients who underwent ton- sillectomy between July 2017 and July 2018. Patients were randomly chosen and they were divided into two groups (thirty patients included in test group received flurbiprofen spray, other thirty included in control group). For test group oral spray flurbiprofen was used 3 times a day, every time three puffs. Postoperative pain was evaluated on the 1st, 4th, 7th and 10th postoperative days. The Efficacy was evaluated by universal pain assessment tool. Wound healing was evaluated on the 1st, 4th, 7th and 10th postoperative days.

Results: The flurbiprofen group include 30 patients (18 males, 12 females) with a mean age of 23 years (range 12-40 years); the control group consisted of 30 patients (16 males, 14 females) with a mean age of 22 years (range12- 40 years). The severity of throat pain was lower in the flurbiprofen group when compared with the control group, and this difference was statistically highly significant for the 4th and the 7th day. Wound healing was not significantly different between the two groups.

Conclusions: The use of flurbiprofen oral spray decreases postoperative tonsillectomy pain.

Downloads

Download data is not yet available.

References

Baugh RF, Archer SM, Mitchell RB et al. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg. 2011; 144:1-30.

Lewis SR, Nicholson A, Cardwell ME, Siviter G, Smith AF. Nonsteroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy. The Cochrane Collaboration. 2013; 7.

D’Souza JN, Schmidt RJ, Xie L, Adelman JP, Nardone HC. Postopera- tive nonsteroidal anti-inflammatory drugs and risk of bleeding in pediatric tonsillectomy. Int J Pediatr Otorhinolaryngol. 2015;79(9):1472-6.

Hansen J, Shah R, Benzon H. Management of pediatric tonsillectomy pain; a review of the literature. Ambulatory Anesthesia. 2016;3, 23-6.

Gao W, Zhang QR, Jiang L, Geng JY. Comparison of local and intravenous dexamethasone for postoperative pain and recovery after tonsillectomy. Otolaryngol Head Neck Surg; 2015;152(3):530-5.

Radkova E, Burova N, Bychkova V, DeVito R. Efficacy of flurbiprofen

75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection: a randomized, non-inferiority trial in the Russian Federation. J Pain Res. 2017; 10: 1591–1600.

Meek IL, Van de Laar MA, E Vonkeman H. Non-Steroidal Anti Inflammatory Drugs; An Overview of Cardiovascular Risks. Pharmaceuticals; 2010 ;3(7): 2146–62.

Riggin L, Ramakrishna J, Sommer DD, Koren G. A 2013 updated systematic review & meta-analysis of 36 randomized controlled trials; no apparent effects of nonsteroidal anti?inflammatory agents on the risk of bleeding after tonsillectomy. Clin Otolaryngol. 2013;38(2):115-29.

Isaacson G. Tonsillectomy healing; Ann Otol Rhinol Laryngol. 2011. ;121(10):645-9.

Syed MI, Magos TA, Singh J, Montague ML.A new analgesia regimen after (adeno) tonsillectomy in children.A pilot study. Clin Otolaryngol. 2016; 41(6):660-5.

Zodpe P1, Cho JG, Kang HJ, Hwang SJ, Lee HM. Efficacy of sucralfate in the postoperative management of uvulopalatopharyngoplasty; a dou- ble-blind, randomized, controlled study. Arch Otolaryngol Head Neck Surg. 2006; 132:1082-5.

Muderris T, Gul F, Yalciner G et al. Oral Flurbiprofen Spray for Post- tonsillectomy Pain. Otolaryngol Head Neck Surg. 2016 J;155(1):166-72.

Fedorowicz Z, Al-Muharraqi MA, Nasser M, Al-Harthy N. Oral rinses, mouthwashes and sprays for improving recovery following tonsillectomy; Cochrane Database Syst Rev. 2010 20;(1): CD007806.

Valijan A. Pain relief after tonsillectomy: effect of benzydamine hydrochloride spray on postoperative pain relief after tonsillectomy. Anaesthesia. 1989; 44:990-1.

Hanc D, Altun H. Effectiveness of hyaluronic acid in post-tonsillec- tomy pain relief and wound healing: a prospective, double-blind, controlled clinical study. Int J Pediatr Otorhinolaryngol. 2015;79(9):1388- 92.

Downloads

Published

2023-06-13

How to Cite

Emin, A. K. H. . (2023). Effect of Flurbiprofen spray on postoperative tonsillectomy pain. AMJ (Advanced Medical Journal) , 5(2), 8-11. https://doi.org/10.56056/amj.2019.92

Issue

Section

Articles