Depression in adolescents with beta-thalassemia major in Erbil city-Iraq

Liqaa Habeeb  Yousif; Selwa Elias  Yacoub

doi:10.56056/amj.2019.93

Authors

Liqaa Habeeb Yousif M.B.Ch.B. Trainee at KHCMS (Family Medicine)
Selwa Elias Yacoub Assistant Professor. MBChB, DCM, FICMS/FM. Trainer at Kurdistan Higher Council of Medical Specialty/Erbil/Iraq

DOI:

https://doi.org/10.56056/amj.2019.93

Keywords:

Adolescence, Beta-thalassemia major, Depression

Abstract

Background and objectives: Depression in adolescent is commonly prevalent with higher rates among patients with thalassemia. The aim of this study is to identify the prevalence of depression in adolescent with beta thalassemia ma- jor attending thalassemia main center in Erbil city /Iraq.

Methods: A cross-sectional study with comparison group was carried out in Thalassemia main center, Ainkawa primary health care center, and Raparin pediatric teaching hospital in Erbil city for the period from April to August 2018. One hundred adolescent of thalassemia patients and that of normal ones ageing 10-19 years were enrolled. Patient Health Questionnaire - 9 used as a screening tool for depression and those with scores of ?10 classified to have depression.

Results: The prevalence of depression among thalassemia adolescents was 67%, compared with 21% of comparison group. Mild depression was the most frequently reported category among both groups while moderate and severe ones were significantly higher among thalassemia patients. Gender, educational level, residency in rural area and suicidal risk were significantly associated with adolescence depression in both study groups.

Conclusions: Depression among thalassemia adolescents is three folds higher than that of comparison group. Screening of depression could be a fundamental component of the health services provided for thalassemia patients to optimize the quality of their life.

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References

Hakeem GLA, Mousa SO, Moustafa AN, Mahgoob MH, Hassan EE. Health-related quality of life in pediatric and adolescent patients with transfusion-dependent ß-thalassemia in Upper Egypt (single center study). Health and Quality of Life Outcomes. 2018; 16(1):59.

Hamed H, Ezzat O, Hifnawy T. Psychological manifestations in ad- olescents with thalassemia. Middle East Current Psychiatry. 2011; 18(4):237-44.

Ismail DK, El-Tagui MH, Hussein ZA, Eid MA, Aly SM. Evaluation of health-related quality of life and muscular strength in children with beta-thalassemia major. Egyptian Journal of Medical Human Genetics. 2018; 19(4):353-7.

Al-Allawi NA, Hassan KM, Sheikha AK, Nerweiy FF, Dawood RS, Jubrael J. beta-Thalassemia Mutations among Transfusion-Dependent Thalassemia Major Patients in Northern Iraq. Molecular biology international. 2010. doi: 10.4061/2010/479282.

De Sanctis V, Kattamis C, Canatan D, et al. -Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. Mediterranean Journal of Hematology and Infectious Diseases. 2017; 9(1): e2017018.

Moafi A, Mobaraki G, Sadr Taheri S, Heidarzadeh A, Shahabi I, Majidi F. Zinc in Thalassemic Patients and Its Relation with Depression. Biological trace element research. 2008; 123: 8-13.

Platania S, Gruttadauria S, Citelli G, Giambrone L, Di Nuovo S. Associations of Thalassemia Major and satisfaction with quality of life: The mediating effect of social support. Health Psychology Open. 2017; 4(2): doi: 10.1177/2055102917742054.

Yengil E, Acipayam C, Kokacya MH, Kurhan F, Oktay G, Ozer C. Anxiety, depression and quality of life in patients with beta-thalassemia major and their caregivers. International Journal of Clinical and Experimental Medicine. 2014; 7(8):2165-2172.

Siddiqui SH, Ishtiaq R, Sajid F, Sajid R. Quality of life in patients with thalassemia major in a developing country. Journal of the College of Physicians and Surgeons Pakistan. 2014; 24(7), 477-480.

Yalçn SS, Durmusoglu-Sendogdu M, Gümrük F, Ünal S, Karg E, Tugrul B. Evaluation of the Children with -Thalassemia in Terms of Their Self-concept, Behavioral, and Parental Attitudes. Journal of Pediatric Hematology/Oncology. 2007; 29(8):523-8.

Maheri A, Sadeghi R, Shojaeizadeh D, Tol A, Yaseri M, Rohban A. Depression, Anxiety, and Perceived Social Support among Adults with Beta-Thalassemia Major: Cross-Sectional Study. Korean Journal of Family Medicine. 2018; 39(2):101-7.

Brent DA, Birmaher B. Adolescent Depression. New England Journal of Medicine. 2002; 347(9):667-71.

Lewandowski RE, Acri MC, Hoagwood KE, et al. Evidence for the Management of Adolescent Depression. Pediatrics. 2013; 132(4): e996-e1009.

Clark MS, Jansen KL, Cloy JA. Treatment of childhood and adolescent depression. Am Fam physician. 2012; 86(5):442-8.

Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression Severity measure. J Gen Intern Med. 2001; 16:606–13.

Lim GY, Tam WW, Lu Y, Ho CS, Zhang MW, Ho RC. Prevalence of Depression in the Community from 30 Countries between 1994 and 2014. Scientific Reports. 2018; 8(1):2861.

Pattanashetti M, Mugali J, Pattanashetty N, Patil S A. Study of Severity of Depression in Thalassemia Patients, International Journal of Indian Psychology. 2017; 4(2): 85.

Ghanizadeh A, Khajavian S, Ashkani H. Prevalence of psychiatric disorders, depression, and suicidal behavior in child and adolescent with thalassemia major. Journal of pediatric hematology/oncology. 2006; 28(12):781-4.

Aydinok Y, Erermis S, Bukusoglu N, Yilmaz D, Solak U. Psychosocial implications of Thalassemia Major. Pediatr Int. 2005; 47:84–89.

Sharghi A, Karbakhsh M, Nabaei B, Meysamie A, Farrokhi A. Depression in mothers of children with thalassemia or blood malignancies: a study from Iran. Clin Pract Epidemiol Ment Health. 2006; 2:27.

Aziz K, Sadaf B, Kanwal S. Psychosocial problems of Pakistani parents of Thalassemic children: a cross-sectional study done in Bahawalpur, Pakistan. Biopsychosoc Med. 2012; 6:15.

Cakaloz B, Cakaloz I, Polat A, Inan M, Oguzhanoglu NK. Psychopathology in thalassemia major. Pediatr Int. 2009;51: 825–28.

Rohde P, Beevers CG, Stice E, O’Neil K. Major and minor depression in female adolescents: onset, course, symptom presentation, and demographic associations. J Clin Psychol. 2009; 65(12):1339-49.

Magklara K, Bellos S, Niakas D, et al. Depression in late adolescence: a cross-sectional study in senior high schools in Greece. BMC Psychiatry. 2015; 15:199.

Boyd CP, Aisbett DL, Francis K, Kelly M, Newnham K. Issues in rural adolescent mental health in Australia. Rural and Remote Health. 2006; 6(1): 501.

Rajkumar S, Hoolahan B. Remoteness and issues in mental health care: Experience from rural Australia. Epidemiologia e Psichiatria Sociale. 2004; 13(2): 78-82.

Koutelekos J, Haliasos N. Depression and Thalassemia in children, adolescents and adults Health Science Journal. 2013; 7(3): 239-246.

Carballo J, Muñoz-LorenzO L, Blasco-Fontecilla H, Lopez-Castroman J, García-Nieto R, Dervic K. Continuity of Depressive Disorders from Childhood and Adolescence to Adulthood: A Naturalistic Study in Community Mental Health Centers. Prim Care Companion CNS Disord. 2011; 13(5): PCC.11m01150.

Matthews T, Danese A, Wertz J, et al. Social isolation, loneliness and depression in young adulthood: a behavioral genetic analysis. Social psychiatry and psychiatric epidemiology. 2016; 51(3):339-48.