Morbidities among babies of diabetic mothers with variable maternal glycemic control

Authors

  • Zahrah Jamal Hamad MBChB, KHCMS Trainee Pediatrics, Rapareen Pediatric Teaching Hospital, Erbil/Iraq.
  • Abbas Abdulkadir Rabaty MBChB, CABP, DCH. Professor of Pediatrics, College of Medicine, Hawler Medical University, Erbil/Iraq .

DOI:

https://doi.org/10.56056/amj.2020.112

Keywords:

Hypoglycemia, Maternal diabetes, Newborns of diabetic mothers

Abstract

Background and objectives:Diabetes in pregnancy is associated with an increased risk of complications in both the mother and the fetus. Early diagnosis by screening of pregnant women between 24 to 28 weeks of gestation with proper control of diabetes is essential to reduce these adverse neonatal outcomes. This study aims to determine mor- bidities in infants of diabetic mothers with variable maternal glycemic state in comparison to infants of non-diabetic mothers.

Methods:A cross-sectional study (with a comparison group) was carried out at Maternity Teaching Hospital in Erbil City, Kurdistan region, Iraq over 6 months period. Fifty neonates of diabetic mothers were compared with 50 neonates of non-diabetic mothers, matched for gestational age and birth weight. Screening and certain investigations, such as blood glucose, serum calcium, total serum bilirubin, Echocardiography were done for both groups.

Results: Majority of the mothers (72%) had gestational diabetes. Among various complications found in infants of diabetic mothers, hypoglycemia was the most common one (56%) which was significantly higher than that among infants of non-diabetic mothers (26%). Congenital heart disease was also significantly higher in infants of diabetic mothers (36%) compared to infants of non-diabetic mothers (4%). 

Conclusions: Morbidities like hypoglycemia,,polycythemia, and congenital anomalies are more common among babies of diabetic mothers when compared to those of non-dia- betic mothers, and they are the most common complications observed.

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References

Kasper, Dennis L. Harrison’s principles of internal medicine. 19th edi- tion. New York: McGraw Hill Education; 2015; 2:2399-427.

Gleason CA, Devaskar SU. Avery’s Diseases of the Newborn, Elsevier Health Sciences, New York, NY, USA, 9th edition, 2012.

Nold JL, Georgieff MK. Infants of diabetic mothers. Pediatr Clin North Am. 2004;51(3):619-37.

Gomella TL, Conningham MD, Eyal FG, editors. Infant of a diabet- ic mother. Neonatology: a Lange Clinical manual. 6th ed. New Jersey: PrenticeHall International; 2009.534-40.

Ogata ES. Problems of the infant of the diabetic mother. NeoReviews. 2010; 11(11):e627-31.

McCance D, Maresh M, Sacks DA, editors. A practical manual of dia- betes in pregnancy. 2nd ed.USA: John Wiley & Sons; 2017:141-9.

Waldemar AC. The high-risk infant. In: Kleigman RM, Stanton BF, Schor NF (eds). Nelson Textbook of Pediatrics. 20th ed. Philadelphia: Elsevier, WB Saunders company; 2016. p. 818- 20.

Moore LE. Preconception Counseling. In Diabetes in Pregnancy 2018:17-23. Available form:https://link.springer.com/chapter/10.1007%2F978-3-319-65518-5_3. [Accessed 2nd Sept 2018].

Cowett R. The infant of the diabetic mother. Neonatal nutrition and metabolism, 2nd Edition, 2006;466-81.

International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes care. 2010;33(3):676-82.

American Diabetes Association. Standards of Medical Care in Di- abetes 2018. Diabetes Care. 2018;41(Suppl.1): S137–S143. Available from;https://doi.org/10.2337/dc18-S013.

Thompson-Branch A, Havranek T. Neonatal Hypoglycemia. Pediat- rics in review. 2017;38(4):147-57. Available from: https://pedsinreview. aappublications.org/content/38/4/147.

American Academy of Pediatrics Subcommittee on Hyperbilirubine- mia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114(1):297-316.

Remon JI, Raghavan A, Maheshwari A. Polycythemia in the New- born. NeoReviews. 2011;12(1): e20-8. Available from: https://neoreviews.aappublications.org/content/12/1/e20

Ahmed S, Rashid I, Shahzad N, Jan M. Morbidity and Mortality amongst Infants of Diabetic Mothers (IDM) Admitted into Neonatology Unit of GB Pant Children Hospital Srinagar. IOSR-JDMS. 2015;14 (3): 09-13.

Kheir AE, Berair R, Gulfan IG, Karrar MZ, Mohammed ZA. Morbidity and mortality amongst infants of diabetic mothers admitted into Soba university hospital, Khartoum, Sudan. Sudan J Paediatr. 2012; 12(1): 49–55.

Al-Nemri AM, Alsohime F, Shaik AH, et al. Perinatal and neonatal morbidity among infants of diabetic mothers at a university hospital in Central Saudi Arabia. Saudi Med J. 2018;39(6):592-7.

Anjum SK, Yashodha HT. A study of neonatal outcome in infants born to diabetic mothers at a tertiary care hospital. Int J Contemp Pediatr. 2018;5(2):489-92.

Opara PI, Jaja T, Onubogu UC. Morbidity and mortality amongst in- fants of diabetic mothers admitted into a special care baby unit in Port Harcourt, Nigeria. Ital. J. Pediatr. 2010;36(1):77.

Hussain M, Irshad M, Khattak AK, Khan B. Frequency of various neonatal complications in infants born to diabetic mothers-a hospital base study. JPMI. 2011; 25(03): 227-32.

Shirazi H, Riaz S, Mahmood I, Gul S. Neonatal outcome of diabetic pregnancy. Ann Pak Ins Med Sci. 2010;6(2):107-2.

Ashraf S, Mushtaq S. Metabolic Complications and Outcome of In- fants Born to Diabetic Mothers. JRMC. 2018:39-42.

Bheeman B. A study of perinatal and neonatal outcome in infants born to diabetic mothers. . Int J Adv Med. 2015;2(3):246-49.

Alam M, Raza SJ, Sherali AR, Akhtar AS. Neonatal complications in infants born to diabetic mothers. JCPSP. 2006;16(3):212-5.

Kadhum DE, Abbas SS, Khalaf DK. The neonatal outcome in infant born to gestational and pre-gestational diabetic mothers. Iraqi JMC. 2017;15(3):268-74.

Akbariasbagh P, Shariat M, Akbariasbagh N, Ebrahim B. Cardio- vascular malformations in infants of diabetic mothers: a retrospective case-control study. Acta Medica Iranica. 2017:103-8.

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Published

2023-06-22

How to Cite

Hamad, Z. J. ., & Rabaty, A. A. . (2023). Morbidities among babies of diabetic mothers with variable maternal glycemic control. AMJ (Advanced Medical Journal) , 6(1), 7-13. https://doi.org/10.56056/amj.2020.112

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