The effect of propofol versus thiopentone on APGAR score of babies delivered and recovery of pregnant mothers undergoing elective cesarean section


  • Dana Ali Mir Ahmed Department of Anesthesia, University of Sulaimani, Sulaimani, Kurdistan Region
  • Amir Murad Khudadad Boujan Assistant professor, in Anesthesia and ICU, College of Medicine, University of Sulaimani, Sulaimani, Kurdistan Region.



Apgar score, General Anesthesia, Propofol, Thiopentone, Recovery time


Background and objectives: The Apgar score is a vital indicator of the baby's well-being. This study aims to compare the effects of propofol and thiopental anesthetics on babies' Apgar scores and mothers' recovery times, this study was carried out.

Methods: This single-arm interventional study was conducted in Zhyan and Soma Hospital in Sulaimani, Kurdistan Region of Iraq from February 2022 to July 2022. Separate doses of propofol and thiopental were given to 140 pregnant women who were candidates for elective cesarean section in two separate groups. Apgar scores at 1 and 5 minutes after birth, recovery time, and hemodynamic changes before and after the intervention were evaluated and compared.

Results: The results of the diastolic pressure variable after the intervention and the hemodynamic variables were significantly different in each group before and after the intervention (P<0.001). The mean recovery time in propofol and thiopental groups was 21.4 ± 2.4 and 26.0 ± 1.8 minutes, respectively, and they were statistically significantly different (p<0.001). There was a statistically significant difference in the Apgar score at the 5th minute between the two groups (p=0.03). In terms of the need for resuscitation after the first minute, the results were in favor of the propofol group (p<0.001).

Conclusion: Propofol can be used more safely since patients who had anesthesia with it had better hemodynamics, quicker recovery times, neonates with higher Apgar scores, and less need for postpartum resuscitation.


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Patel N. Anesthesia for cesarean delivery. Journal of Advanced Medical and Dental Sciences Research. 2015;3(4):25-29.

Mahjoubifard M, Heidari M, Dahmardeh M, et al. Comparison of Dexmedetomidine, Lidocaine, and Fentanyl in Attenuation Hemodynamic Response of Laryngoscopy and Intubation in Patients Undergoing Cardiac Surgery. Anesthesiol Res Pract. 2020; 4814037.

Moghadam MY, Quchan AD, Eftekhariyazdi M, et al. Effect of General Anesthesia with Thiopental Sodium and Propofol on the 1-and 5 minutes Apgar newborns by Cesarean. AACC. 2021; 7(1): 33-7.

Montandrau O, Espitalier F, Bouyou J, et al. Thiopental versus propofol on the outcome of the newborn after caesarean section: An impact study. Anaesth Crit Care Pain Med. 2019; 38(6): 631-5.

Cnattingius S, Johansson S, Razaz N. Apgar Score and Risk of Neonatal Death among Preterm Infants. N. Engl. J. Med. 2020; 383(1): 49-57.

Tumukunde J, Lomangisi DD, Davidson O, et al. Effects of propofol versus thiopental on Apgar scores in newborns and peri-operative outcomes of women undergoing emergency cesarean section: a randomized clinical trial. BMC Anesthesiol. 2015; 15(1): 63.

Çakrtekin V, Yldrm A, Bakan N, et al. Comparison of the Effects of Sodium Thiopental and Propofol on Haemodynamics, Awareness and Newborns During Caesarean Section Under General Anaesthesia. Turk. J. Anaesthesiol. Reanim. 2015; 43(2): 106-12.

Elshaer E, Omar H, Elshaer A, et al. Comparison between the Effects of Thiopental Sodium and Propofol on Maternal Hemodynamics during Cesarean Section Under General Anesthesia and Apgar score of the newborns. QJM: An International Journal of Medicine. 2020;113: 39-59.

Rabiee, SM, Alijanpour E, Naziri F, et al. A Comparison of Depth of Anesthesia and Hemodynamic Variables with Sodium Thiopental and Propofol as Induction Agents for Cesarean Section. J. Babol Univ. Med. Sci. 2012; 14(5): 7-12.

Khemlani KH, Weibel S, Kranke P, et al. Hypnotic agents for induction of general anesthesia in cesarean section patients: A systematic review and meta-analysis of randomized controlled trials. Journal of Clinical Anesthesia. 2018; 48: 73-80.

Sahraei R, Ghanei M, Radmehr M, et al. The effect of propofol and thiopental on neonate Apgar in induction of cesarean section Anesthesia: A comparative study. Life. Sci. J. 2014; 11(9): 93-5.

Shetabi H, Montazeri K, Ghoodjani Y. A Comparative Study of the Effect of Anesthesia Induction with the Use of Four Drug Combinations Including "Propofol," "Etomidate-Propofol," "Thiopental," and "Midazolam-Thiopental" on Hemodynamic Changes during the Insertion of Laryngeal Mask in Eye Surgery. Adv. Biomed. Res. 2022; 11: 11.

Kayalha H KM, Rastak Sh MP, Sofiabadi M. Comparison of the hemodynamic effects of two anesthetics; sodium thiopental and propofol in patients undergoing electroconvulsive therapy. J. Ardabil Univ. Med. Sci. 2018; 18(3): 357-66.

Ghodrati M, Amani F, et al. Comparison of propofol and thiopental for induction of anaesthesia for elective Caesarean section on Apgar score. Res. Sci. J. Ardabil Univ. Med. Sci. 2003; 3(9): 52-8.

Mercan A, El-Kerdawy H, Khalil M, et al. A prospective, randomized comparison of the effects of thiopental and propofol on bispectral index during caesarean section till delivery of newborn. Mid. East. J. Anesthesiol. 2012; 21(5): 699-704.

Moghadam MY, Quchan AD, Eftekhariyazdi M, Khalili-Shomia S. Effect of General Anesthesia with Thiopental Sodium and Propofol on the 1-and 5 minute Apgar newborns by Cesarean. Arch. of Anes. and Crit. Care. 2021 Feb 3;7(1):33-7.

Dadras MM, Mahjoobifard M, Panahipoor A, et al. Comparing Propofol with Sodium Thiopental on Neonatal Apgar Score after Elective Cesarean Section. Zahedan. J. Res. Med. Sci. 2013; 15(4): e92998.

Golfam P, Karimpur H, Yari M. The effects of propofol and thiopental on Apgar score during cesarean section. J. Kermanshah Univ. Med. Sci. 2010; 14(1): e79537.




How to Cite

Mir Ahmed, D. A., & Boujan, A. M. K. . (2024). The effect of propofol versus thiopentone on APGAR score of babies delivered and recovery of pregnant mothers undergoing elective cesarean section . AMJ (Advanced Medical Journal) , 9(2), 1-10.