Evaluation of Breast Conserving Surgery According  to Molecular Subtypes in Kurdish Females

Shaban Latif  Tofiq; Kamal Ahmad  Saeed

doi:10.56056/amj.2024.255

Authors

Shaban Latif Tofiq General Surgery Board Trainee Kurdistan Higher Council for Medical Specialties (KHCMS) and Sulaimani Teaching Hospital, Ministry of Health, Sulaimaniyah, Iraq.
Kamal Ahmad Saeed FIBMS (General Surgery), Professor, Department of Surgery, College of Medicine, University of Sulaimani, Sulaimaniyah, Iraq

DOI:

https://doi.org/10.56056/amj.2024.255

Keywords:

Breast cancer, Breast-conserving surgery, Cross-sectional study, Margin involvement, Molecular subtype

Abstract

Background & objectives:

The most frequently occurring cancer in women is breast cancer, and various treatment methods are available. Thus, we aimed to correlate between molecular subtype and the suitability of performing breast-conserving surgery.

Methods: This retrospective cross-sectional study was conducted on 300 women with primary breast cancer, but without distant metastasis, from 2016 to 2022. These women had undergone either breast-conserving surgery or mastectomy. Patients were interviewed directly to obtain the necessary data, and their data were recorded on a questionnaire.

Results: The most common age group at diagnosis was 45-50 years, and the mean age for menarche was 13.3±1.3 years. Of the patients, 9% were single, 15% were nulliparous, and 76.7% had practised breastfeeding. The most common type of cancer was invasive ductal carcinoma, with ductal carcinoma in situ (82%). The molecular subtype and type of surgery were significantly correlated (p=0.041). Of the sample, 66.7% underwent breast-conserving surgery, with the highest rate (87%) being done in the triple-negative molecular subtype. Additionally, there was a significant correlation between the tumour focality and the postoperative margin (p<0.001).

Conclusions: Triple-negative cases were the most suitable for breast-conserving surgery among the molecular subtypes and had the highest rate of free margin. In contrast, unifocal breast cancers had the least involvement in margin postoperatively.

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