Clinical and Dermoscopic evaluation of post acne erythema after treatment with topical timolol maleate 0.5%

Sawen Jihanger  Omer; Mohammed Yousif Saeed  Jaf; Shawkat Abubakr  Hassan

doi:10.56056/amj.2024.258

Authors

Sawen Jihanger Omer KHCMS/ Dermatology trainee, Sulaymaniyah Dermatology Teaching Hospital, KRG, Iraq
Mohammed Yousif Saeed Jaf FIBMS (Dermatology), ISDS, ESLDC, Assistant Professor of Dermatology, University of Sulaimani, college of medicine, Head of Sulaymaniyah Dermatology Teaching centre.
Shawkat Abubakr Hassan ABMS/Dermatology lecturer, Sulaymaniyah Dermatology Teaching Hospital, KRG, Iraq

DOI:

https://doi.org/10.56056/amj.2024.258

Keywords:

Acne, Dermoscopy, Post-acne erythema, Timolol maleate

Abstract

Background and objectives: A common consequence of acne inflammation is called post-acne erythema, which describes telangiectasia and erythematous lesions that persist even after acne treatment, although some post-acne erythema lesions may become better with time. For some patients, having prolonged post-acne erythema might not be acceptable. Many studies have assessed the effectiveness of various post-acne erythema therapeutic approaches; however, there is no standard treatment. The aim of this study was to evaluate efficacy and safety of topical timolol maleate 0.5% in the treatment of post-acne erythema clinically and by dermoscopy.

Methods: A randomized therapeutic clinical trial conducted in Sulaimanyah city-Kurdistan region over a period from March to September of 2022.Thirty patients (24 female and 6 male) with persistent post-acne erythema were enrolled in this study. Treatments with timolol 0.5% ophthalmic solution: apply 3-5 drops of timolol over the affected area every night at bedtime for 12 weeks. Our objectives were patient satisfaction, dermoscopy-assessed erythema assessment, and physician-reported clinical improvement.

Result: After 12 weeks of treatment, there were no patients with severe erythema, clinically and statistically; there was a marked decline in the mean clinician erythema score and its standard deviation from 2.7± 0.98 to 1.0 ± 1.0 Also by dermoscopy-assessed erythema assessment, there was a substantial decrease in the mean erythema score and its standard deviation from 2.0±0.72 to 0.70±0.70, no participants after therapy exhibited severe erythema by dermoscopy.so statistically there is significant reduction in erythema clinically and dermoscopically.

Conclusion: The results of this study show that there was very good response of post-acne erythema lesions with no obvious side effects, further therapeutic clinical studies with larger sample size is needed.

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