Central Corneal Thickness: Comparison between diabetics and nondiabetics
DOI:
https://doi.org/10.56056/amj.2024.275Keywords:
Central Corneal Thickness, Corneal Endothelium, Diabetes MellitusAbstract
Background and objectives: The cornea play a significant role in eye refraction. With early detection and prompt treatment, ocular problems linked to diabetes mellitus can be prevented from progressing. The purpose of this study was to compare the central corneal thicknesses of diabetic and non-diabetic patients.
Methods: In Duhok Teaching Eye Hospital; a comparative cross-sectional study had been conducted between 01.01.2022 and 30.06.2022. There were 100 participants, 50 in diabetes group, and 50 in a control group. The diabetic group is further subdivided into three categories based on the duration of diabetes (less than 5 years, more than 5 to10 years, and above 10 years), as well as two subgroups based on the type of diabetes mellitus (type I and type II). The thickness of the central cornea was measured using SIRIUS corneal pachymetry and topography.
Results: There was no statistically significant difference between the non-diabetic and diabetic groups in terms of central corneal thickness (549.6 micrometers 541.4 micrometers, P > 0.05). There was a statistically significant difference (P 0.05) between the mean central corneal thickness of diabetics with diabetes mellitus for more than ten years and non-diabetics and diabetics with diabetes for five years.
Conclusion: In comparison to both non-diabetics and diabetics with diabetes for five years or less, those with long-term diabetes mellitus (diabetes for more than ten years) had a bigger statistically significant average central corneal thickness.
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References
Levin LA, Nilsson SF, Ver Hoeve J, Wu S, Kaufman PL, Alm A. Adler's Physiology of the Eye E-Book. Elsevier Health Sciences. 2011; 4:173-5.
Bowling B. Kanski's Clinical Ophthalmology E-Book: A Systematic Approach. Elsevier Health Sciences. 2015; 6:168.
Daniel HW, Tien YW, Wang LW, Seang MS, Donald TH, Sunny YS, et al. Diabetes, Hyperglycemia, and Central Corneal Thickness: the Singapore Malay Eye Study. Ophthalmology. 2008; 115(6): 964-8.
Gupta HL, Yadav M, Sundarka MK, Talwar V, Saini M, Garg P. A study of prevalence of health problems in asymptomatic elderly individuals in Delhi. J Assoc Physicians India. 2002; 50:792-5.
Sayin N, Kara N, Pekel G. Ocular complications of diabetes mellitus. World J Diabetes. 2015; 6(1):92-108.
Kotecha A, Oddone F, Sinapis C, Elsheikh A, Sinapis D, Sinapis A, et al. Corneal biomechanical characteristics in patients with diabetes mellitus. J Cataract Refract Surg. 2010; 36:1822–8.
Ljubimov AV. Diabetic complications in the cornea. Vision Res. 2017; 139:138-52.
Priyadaarsini S, Whelchel A, Nicholas S, Sharif R, Riaz K, Karamamichos D. Diabetic keratopathy: Insights and challenges. Surv Ophthalmol. 2020; 65(5):513-29.
Mocan M, Irkec M, Orhan M. Evidence of Waite–Beetham lines in the corneas of diabetic patients as detected by in vivo confocal microscopy. Eye (Lond). 2006; 20(12):1488-90.
Steele C, Steel D, Waine C. Diabetes and the eye. Elsevier Health Sciences. 2008; 9:182.
El-Agamy A, Alsubaie S. Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus. Clin Ophthalmol. 2017; 11:481-6.
Akyol Salman, Azizi S, Mumcu U, Önda O, Baykal O. Central corneal thickness in patients with meibomian gland dysfunction a. Clin Exp Optom. 2011; 94(5):464-7.
Mathebula SD, Segoati TM. Is the central corneal thickness of diabetic patients thicker than that of non-diabetics’ eyes Afr Vision Eye Health. 2015; 74(1).
Kadhim YJ, Farhood QK. Central corneal thickness of Iraqi population in relation to age, gender, refractive errors, and corneal curvature: a hospital-based cross-sectional study. Clin Ophthalmol. 2016; 10:2369-76.
Riyam FR, Farhood QK. Measurement of central corneal thickness by ultrasonic pachymeter and oculus pentacam in patients with well-controlled glaucoma: hospital-based comparative study. Clin Ophthalmol. 2016; 10:359–64.
Sudhir RR, Raman R, Sharma T. Changes in the corneal endothelial cell density and morphology in patients with type 2 diabetes mellitus: a population-based study, Sankara Nethralaya Diabetic Retinopathy and Molecular Genetics Study (SN-DREAMS, Report 23). Cornea. 2012; 31(10):1119-22.
Wiemer NG, Dubbelman M, Kostense PJ, Ringens PJ, Polak BC. The influence of chronic diabetes mellitus on the thickness and the shape of the anterior and posterior surface of the cornea. Cornea. 2007; 26(10):1165-70.
Briggs S, Osuagwu UL, AlHarthi EM. Manifestations of type 2 diabetes in corneal endothelial cell density, corneal thickness and intraocular pressure. J Biomed Res. 2015; 30(1):46.
Shifa PN. Effect of Diabetes Mellitus on Central Corneal Thickness–A Comparative Study. Pak J Ophthalmol. 2017; 33(3):127.
Rashmi Kumari, Bhawesh Chandra Saha. Central corneal thickness and diabetes – a study of correlation in terms of duration and glycemic control. Int J Contemp Med Res 2017; 4(3):767-9.
Singh M, Anand A, Sinha BP, Prasad N, Mishra S. Changes in central corneal thickness in diabetes mellitus patients J. Evid. Based Med. Healthc. 2018; 5(26):1986-9.
Eballe AO, Koki G, Ellong A, Owono D, Epée E, Bella LA, et al. Central corneal thickness and intraocular pressure in the Cameroonian nonglaucomatous population. Clini Ophthalmol. 2010; 4:717-24.
Lekskul M, Aimpun P, Nawanopparatskul B, Bumrungsawat S, Trakulmungkijkarn T, Charoenvanichvisit J, et al. The correlations between Central Corneal Thickness and age, gender, intraocular pressure and refractive error of aged 12-60 years old in rural Thai community. J Med Assoc Thai. 2005; 88:S175-9.
Turgut FG, Turgut A, Dolgun ZN, Köroglu N. Effects of menopause on corneal topography and dry eye. Int J Reprod Contracept Obstet Gynecol. 2017; 6(2):461-5.
Rashmi S, Soni Soman D, Anupama B, Jain R, Akshaya KM. Do Postmenopausal Women have Thinner Central Corneal Thickness as Compared to Women in Reproductive Age Group?. Int J Sci Res. 2016; 5(3):2188-91.
Varghese VO, Vadakkemadam LN, Jacob S, Praveena KK, Raj R, Kizhakkepatt J. Study of factors influencing central corneal thickness among patients attending ophthalmology outpatient department at a tertiary care center in North Kerala. Kerala J Ophthalmol. 2016; 28(3):193.
Lee JS, Oum BS, Choi HY, Lee JE, Cho BM. Differences in corneal thickness and corneal endothelium related to duration in diabetes. Eye (Lond). 2006; 20(3):315-8.
Altay Y, Burcu A, Ornek F. The change in central corneal thickness after successful control of hyperglycemia in diabetic patients. Int Eye Sci. 2014; 14(4):575-8.
Abdulghani YS, Ali TO. Correlation between central corneal thickness and diabetes in sudanese patients. Natl J Med Res. 2013; 3(4):3.
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Copyright (c) 2024 Mohammed Muneer Labeeb, Neshiteman Hashim Abdulrahman, Khosro Senyar Tato
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