Thyroid Dysfunction and Anti Thyroid Autoantibodies among Type I Diabetes Mellitus Patients
DOI:
https://doi.org/10.56056/416Keywords:
Autoimmune thyroid disease, Type I diabetes mellitus, Thyroid Peroxidase antibodiesAbstract
Background and objectives: Studies have shown a strong association between Type I diabetes and autoimmune thyroid diseases, particularly autoimmune thyroiditis, with higher rates of thyroid autoantibodies in diabetic patients. Our aim is to study the prevalence of undiagnosed thyroid dysfunction and positive thyroid autoantibodies in Type I diabetes patients.
Methods: This was an observational analytic cross?sectional study conducted at Layla Qasim Diabetes Center in Erbil City, Kurdistan Region-Iraq. A total of 86 type I diabetes patients were enrolled during the period between November 2022 and August 2023. We conducted various laboratory tests for all study participants, including thyroid-stimulating hormone, triiodothyronine, thyroxine, fasting blood glucose, glycated hemoglobin, anti-thyroid peroxidase, and Thyroid Stimulating Hormone receptor antibodies.
Results: Among the participant patients 8.1% of them had hypothyroidism, and 10.5% had subclinical hypothyroidism and 9.3% of patients had thyroid-stimulating-hormone antibodies, 15.1% had Thyroid Peroxidase antibodies, and 3.5% had both of them. Among patients with hypothyroidism, higher proportion (85.7%) had positive Thyroid Peroxidase antibodies followed by those with subclinical hypothyroidism (55.6%), while in patients with normal thyroid function positive Thyroid Peroxidase antibodies were found in only 2.9% with highly significance difference (p-value <0.001).
Conclusion: Higher rates of autoimmune thyroid diseases and positive thyroid antibodies have been reported in patients with type I diabetes mellitus.
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Copyright (c) 2025 Farznda Mustafa Salih Zebari, Farznda Mustafa Salih Zebari, Halgurd Fathulla Ahmed
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