The Efficacy of Nano-water in Combination with Tamsulosin-Dutasteride for Alleviating Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

Alaa  Al Krush; Ali  Sami; Safaa  Almukhtar; Ismael  Weas

doi:10.56056/

Authors

Alaa Al Krush FRCP, Assistant Professor of Medicine and Nephrology, Department of Medicine, College of Medicine, University of Sulaimani, Sulaymaniyah, Iraq.
Ali Sami FIBMS (Urology), Lecturer of Urology, Department of Surgery, College of Medicine, University of Sulaimani, Sulaymaniyah, Iraq.
Safaa Almukhtar CABM (Medicine), CABM (nephrology), Professor of Medicine and Nephrology, Department of Medicine, College of Medicine, Hawler Medical University, Erbil, Iraq.
Ismael Weas FIBMS (Urology), Professor of Urology, Department of Surgery, College of Medicine, University of Sulaimani, Sulaymaniyah, Iraq.

DOI:

https://doi.org/10.56056/

Keywords:

Benign prostatic hypertrophy, Lower urinary tract symptoms, Nano-water

Abstract

Background and Objectives: Symptoms of the Lower urinary tract are common in benign prostatic hyperplasia. This study assessed the effectiveness of Nano-water doubled with tamsulosin-dutasteride in improving these symptoms.

Methods: This double-blind, randomized study was conducted in Sulaimani, Iraq, from February 2016 to November 2022. The study included 193 men with an International Prostatic Symptom Score of 13 or higher, peak urine flow rates of 15 milliliters per second or less, and prostatic volumes between 30 and 80 cubic centimeters. The participants were randomly assigned to two groups. Group A (97 men) received Nano-water with tamsulosin-dutasteride, while Group B (96 men) obtained regular water with the same medication. Assessments at baseline and after three months included the International Prostatic Symptom Score, peak urine flow rate, and residual urine volume.

Results: Group A demonstrated more remarkable results than Group B. The International Prostatic Symptom Score fell to 6.67 in Group A compared to 10.87 in Group B. Peak urine flow rates climbed to 17.48 milliliters per second in Group A versus 15.45 milliliters per second in Group B. Residual urine was less than 50 milliliters in 88 percent of Group A patients compared to 75 percent in Group B. All results were statistically significant.

Conclusions: Nano-water combined with tamsulosin-dutasteride improved lower urinary tract symptoms in men with benign prostate hyperplasia.

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