Glycemic Gap, Clinical, Angiographic Characteristics and In-hospital Outcomes of Diabetic Patients Presenting with Acute Coronary Syndrome undergoing Primary Percutaneous Coronary Intervention

Herish Adil  Ahmed; Rafid Fayadh  Al-Aqeedi

doi:10.56056/

Authors

Herish Adil Ahmed MD, Surgical Specialty Hospital, Erbil Cardiac Center, Erbil, Iraq, Kurdistan Higher Council of Medical Specialties (KHCMS), Cardiovascular Medicine,
Rafid Fayadh Al-Aqeedi DM (Med), FIBMS, MRCP (London), DM (Int. Cardiology), FACC, FESC. Consultant Interventional Cardiologist, Surgical Specialty Hospital, Erbil Cardiac Center, Erbil, Iraq

DOI:

https://doi.org/10.56056/

Keywords:

Acute coronary syndrome, Diabetes, Glycemic gap, Hyperglycemia, Major adverse cardiac events

Abstract

Background and objectives: a number of severe illnesses have been linked to the glycemic gap which is the difference between estimated average glucose and blood glucose at admission as a potential prognostic indicator, it's function in individuals with acute coronary syndrome is still unclear, nevertheless, this study aims to evaluate the glycemic gap in acute coronary syndrome patients as well as its correlation with clinical outcomes, including length of hospital stay and occurrence of complications.

Methods: Between January 1st and April 1st, 2023, we performed a prospective cohort study with 100 patients who were admitted with acute coronary syndrome at Surgical Specialty Hospital, Erbil Cardiac Center, a glycemic gap calculation was made, the clinical outcomes were evaluated and the prognostic importance of the glycemic gap was ascertained by multivariate analysis.

Results: Mean age was 61.77 ± 10.44 years, with 55% being male and 45% female, the mean admission blood glucose level was 256.47 ± 63.90 mg/dL, mean glycemic gap was 77± 61mg/dl, and the mean HbA1c level was 7.8% ± 0.82%, there was no significant difference between the two groups admission random blood glucose levels (p = 0.789), but diabetic patients who encountered major adverse cardiac events had a substantially higher glycemic gap than those who did not (p < 0.001).

Conclusion: Based on our research, patients with acute coronary syndrome may benefit from using the glycemic gap as a useful prognostic indicator, in the regular treatment of acute coronary syndrome patients.

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