Evaluation of Barriers of Achieving Timely Primary Percutaneous Coronary Intervention in Patients with STelevation Myocardial Infarction in Sulaimani Cardiac Hospital

Authors

  • Hawkar Rashid Taha MBChB, FIBMS, KHCMS- Department of Cardiology, Sulaimani Cardiac Hospital, Sulaimani, Kurdistan Region, Iraq.
  • Hussein Murad Muhamad MBChB, FIBMS, Interventional Cardiologist, Sulaimani, Cardiac Hospital, Sulaimani, Kurdistan Region, Iraq.
  • Amar Talib Al-Hamdi MBChB, MRCP (UK), Professor of Medicine/Cardiology, Senior Consultant Cardiolo-gist/Electrophysiologist, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.

DOI:

https://doi.org/10.56056/

Keywords:

Primary percutaneous coronary intervention, ST elevation myocardial infarction, Total ischemic time

Abstract

Background and objectives: An estimated increase in risk of death exists for patients with ST
elevation myocardial infarction. Primary percutaneous coronary intervention may lower this risk 
if only performed on time. The aim of this study is to evaluate the barriers to achieving timely 
primary percutaneous coronary intervention. 
Methods: This is an observational/cross-sectional study conducted in Sulaimani city, Kurdistan 
Region of Iraq, from February 1, 2024, to January 31, 2025, on 200 patients with ST elevation 
myocardial infarction, assessment of time intervals from symptom onset to balloon, and the factors 
contributing to delay of primary percutaneous coronary intervention included in the questionnaire. 
Results: Most of the patients (80.1%) were male; the mean age was 60.69 ± 12.16 years. 132 
patients, 69.1%, had a timely door to balloon time (≤ 60 minutes). The median door-to-balloon 
time was 50 minutes (IQR 25-75: 10-10200 minutes). Median total ischemic time was 380 minutes 
(IQR 25-75: 60-2950 minutes). 19 (10%) had timely total ischemic time (≤ 120 minutes). 
statistically significant correlation with gender, door in to door out time, symptom to door time, 
and door to balloon time (P = 0.016, <0.001). Barriers that significantly prolong total ischemic 
time were patient delay, non-percutaneous coronary intervention-capable center delay, delay 
during transfer to the PCI center (P <0.001), and delay team activation. 
Conclusion: Timely reperfusion is the mainstay of acute STEMI management. This study 
discovered that the main barriers of timely primary percutaneous coronary intervention are a 
patient’s delay to present to the hospital, longer duration of remaining in non-PCI facility hospital, 
and delaying during transferring to PCI-capable center. Focusing on patients’ education and 
alertness programs for acute chest pain are essential for enhancing total ischemic time. 

Downloads

Download data is not yet available.

References

1.

Libby P. Braunwald's heart disease

E-book: a textbook of cardiovascular

medicine. Elsevier Health Sciences. 2021 Oct

15;12: 636-1902.

https://doi.org/10.56056/amj.2026.451

7

https://amj.khcms.edu.krd

Evaluation of Barriers of Achieving Timely Primary Percutaneous Coronary Intervention in Patients….

2.

Chan AW, Kornder J, Elliott H,

Brown RI, Dorval JF, Charania J, et al.

Improved survival associated with pre

hospital triage strategy in a large regional ST

segment elevation myocardial infarction

program. JACC: Cardiovasc Interv. 2012

Dec;5(12):1239-46.

3.

Hong MK. Recent Advances in the

Treatment

of

Myocardial

2012(1):683683.

4.

ST‐Segment

Infarction.

Elevation

Scientifica.

Fordyce CB, Al-Khalidi HR, Jollis

JG, Roettig ML, Gu J, Bagai A, et al.

Association

of

rapid

care

process

implementation on reperfusion times across

multiple ST-segment–elevation myocardial

infarction networks. Circ Cardiovasc Interv.

2017 Jan;10(1): e004061.

5.

Stowens JC, Sonnad SS, Rosenbaum

RA. Using EMS dispatch to trigger STEMI

alerts decreases door-to-balloon times. West

J Emerg Med 2015; 16(3):472–480.

6.

Squire BT, Tamayo-Sarver JH, Rashi

P, Koenig W, Niemann JT. Prehospital

cardiac catheterization lab activation affects

door-to-balloon time, mortality, and false

positive activation. Prehosp Emerg Care

2014; 18(1):1–8.

7.

Nallamothu BK, Normand SL, Wang

Y, Hofer TP, Brush JE, Messenger JC, et al.

Relation between door-to-balloon times and

mortality

after

coronary

primary

intervention

percutaneous

over

retrospective

study.

385(9973):1114–1122.

8.

Lancet

time:

a

2015;

Mohialdeen D, Arif M, Mawlood S.

Door-to-balloon time and cardiovascular

outcomes in patients with ST- elevation

myocardial infarction treated with primary

percutaneous coronary intervention. J.

Sulaimani Med. Coll. 2022 Jun 21;12(2): 71

165.

9.

Solhpour A, Chang KW, Arain SA,

Balan P, Loghin C, McCarthy JJ et al.

Ischemic time is a better predictor than door

to‐balloon time for mortality and infarct size

in

ST‐elevation myocardial infarction.

Catheter Cardiovasc Interv. 2016 Jun;87(7):

1194-200.

10.

al.

Ibanez B, James S, Agewall S,

Antunes MJ, Bucciarelli-Ducci C, Bueno H,

et

2017 ESC Guidelines for the

management of acute myocardial infarction

in

patients presenting with ST-segment

elevation:

The Task Force for the

management of acute myocardial infarction

in

patients presenting with ST-segment

elevation of the European Society of

Cardiology (ESC). Eur Heart J. 2018 Jan

7;39(2):119-77.

11.

Khowaja S, Ahmed S, Kumar R, Shah

JA, Khan KA, Khan NU, et al. Time to think

beyond door to balloon time: significance of

total ischemic time in STEMI. Egypt Heart J.

2021 Dec; 73:1-7.

12.

Prasad A, Gersh BJ, Mehran R,

Brodie BR, Brener SJ, Dizon JM, et al. Effect

of ischemia duration and door-to-balloon

time on myocardial perfusion in ST-segment

elevation myocardial infarction: an analysis

from HORIZONS-AMI Trial (Harmonizing

Outcomes with Revascularization and Stents

in Acute Myocardial Infarction). JACC:

Cardiovasc Interv. 2015 Dec 28;8(15):1966

74.

13.

Khalid U, Jneid H, Denktas AE. The

relationship between total ischemic time and

mortality in patients with STEMI: every

second counts. Cardiovasc Diagn Ther. 2017

Jun;7(Suppl 2): S119.

14.

Hocagil H, Hocagil AC. Primary

Preventable Cause of Door-in to Door-out

Time Delay in ST-elavation Myocardial

Infarction:

Physician

Decision

Time.

Eurasian J Emerg Med. 2024 Mar 1; 23(1).

15.

Doddipalli

total

SR,

Rajasekhar

D,

Vanajakshamma V, Naik KS. Determinants

of

ischemic time in primary

percutaneous coronary interventions. Indian

Heart J. 2018 Dec 1; 70: 275-279.

16.

Shi O, Khan AM, Rezai MR,

Jackevicius CA, Cox J, Atzema CL, et al.

https://doi.org/10.56056/amj.2026.451

8

https://amj.khcms.edu.krd

Evaluation of Barriers of Achieving Timely Primary Percutaneous Coronary Intervention in Patients….

Factors associated with door-in to door-out

delays

among

ST-segment

elevation

myocardial infarction (STEMI) patients

transferred

for

primary

percutaneous

coronary intervention: a population-based

cohort study in Ontario, Canada. BMC

Cardiovasc Disord. 2018 Dec; 18:1-9.

17.

Emami M, Mirzamohamadi S,

Heidari A, Aein A, Salarifar M, Nematipour

E. Evaluation of the Causes of Door-to

Balloon Time Delays in Patients with ST

Elevation Myocardial Infarction at Tehran

Heart Center. J Tehran Heart Cent. 2023

Jan;18(1):68.

18.

Babiolakis CS, Sharma S, Sayed N,

Abunassar JG, Haseeb S, Abuzeid W. The

effect of sex on door-to-balloon time in

patients

presenting

with

ST-elevation

myocardial infarction and referred for

primary percutaneous coronary intervention:

a systematic review. Cardiovasc Revasc

Med. 2022 Apr 1; 37:120-7.

19.

Hameed SM, Schuurman N, Razek T,

Boone D, Van Heest R, Taulu T, et al. Access

to trauma systems in Canada. J Trauma. 2010

Dec 1;69(6):1350-61.

20.

Park J, Choi KH, Lee JM, Kim HK,

Hwang D, Rhee TM, et al. Prognostic

implications of door‐to‐balloon time and

onset‐to‐door time on mortality in patients

with

ST‐segment–elevation

myocardial

infarction treated with primary percutaneous

coronary intervention. J Am Heart Assoc.

2019 May 7;8(9): e012188.

21.

Chandrasekhar J, Marley P, Allada C,

McGill D, O’Connor S, Rahman M, et al.

Symptom-to-balloon time is a strong

predictor of adverse events following

primary percutaneous coronary intervention:

results from the Australian Capital Territory

PCI Registry. Heart Lung Circ. 2017 Jan

1;26(1):41-8.

22.

Dakota I, Dharma S, Andriantoro H,

Firdaus I, Danny SS, Zamroni D, et al. Door

in to door-out delay in patients with acute ST

segment elevation myocardial infarction

transferred

for

primary

percutaneous

coronary intervention in a metropolitan

STEMI network of a developing country.Int

J Angiol. 2020 Mar;29(1):27-32.

23.

Zamani B, Ghadimi S, Moradoghli F,

Chenaghlou M, Separham A, Amirajam Z, et

al. Associated factors with delayed door to

balloon time in STEMI Patients. Int J

Cardiovasc Pract. June 2021; 6 (1): e131479.

24.

Li L, Wu MY, Zhang F, Li SF, Cui

YX, Hu D, et al. Perspective of delay in door

to-balloon time among Asian population. J

Geriatr Cardiol: JGC. 2018 Dec;15(12):732.

25.

Ikemura N, Sawano M, Shiraishi Y,

Ueda I, Miyata H, Numasawa Y, et al.

Barriers associated with door-to-balloon

delay in contemporary Japanese practice.

Circ J. 2017 May 25;81(6):815-22.

Downloads

Published

2026-06-01

Issue

Section

Articles

How to Cite

Evaluation of Barriers of Achieving Timely Primary Percutaneous Coronary Intervention in Patients with STelevation Myocardial Infarction in Sulaimani Cardiac Hospital. (2026). AMJ (Advanced Medical Journal) , 11(2), 1-9. https://doi.org/10.56056/